ROS1, Recombinant, Arabidopsis thaliana, aa1-320, His-SUMO-Tag (Protein ROS1)

ROS1, Recombinant, Arabidopsis thaliana, aa1-320, His-SUMO-Tag (Protein ROS1)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
375084.20 20 µg - -

3 - 19 Werktage*

511,00 €
375084.100 100 µg - -

3 - 19 Werktage*

818,00 €
 
Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and... mehr
Produktinformationen "ROS1, Recombinant, Arabidopsis thaliana, aa1-320, His-SUMO-Tag (Protein ROS1)"
Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (PubMed:25240767). Generates 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) as a primary 5-meC excision intermediate (PubMed:25228464). Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. Highly distributive behavior on DNA substrates containing multiple 5-meC residues. Involved with Pol IV in the remodeling of the 5S rDNA chromatin via DNA methylation modifications during the first days of development post-germination. Participates in UV-B induced- and oxidative DNA damage repair (PubMed:24155752). Source: Recombinant protein corresponding to aa1-320 from arabidopsis thaliana ROS1, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~52.3kD, AA Sequence: MEKQRREESSFQQPPWIPQTPMKPFSPICPYTVEDQYHSSQLEERRFVGNKDMSGLDHLSFGDLLALANTASLIFSGQTPIPTRNTEVMQKGTEEVESLSSVSNNVAEQILKTPEKPKRKKHRPKVRREAKPKREPKPRAPRKSVVTDGQESKTPKRKYVRKKVEVSKDQDATPVESSAAVETSTRPKRLCRRVLDFEAENGENQTNGDIREAGEMESALQEKQLDSGNQELKDCLLSAPSTPKRKRSQGKRKGVQPKKNGSNLEEVDISMAQAAKRRQGPTCCDMNLSGIQYDEQCDYQKMHWLYSPNLQQGGMRYDAI, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: DML1, ROS1, F1O11.12, At2g36490, EC=3.2.2.-, Protein ROS1, DEMETER-like protein 1, Repressor of silencing 1
Hersteller: United States Biological
Hersteller-Nr: 375084

Eigenschaften

Konjugat: No
MW: 52,3
Format: Purified

Datenbank Information

UniProt ID : Q9SJQ6 | Passende Produkte
Gene ID : GeneID 818224 | Passende Produkte

Handhabung & Sicherheit

Lagerung: °C
Versand: °C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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