Recombinant Rat LAG3/CD223 Protein (His Tag) (RPES4468)

Recombinant Rat LAG3/CD223 Protein (His Tag) (RPES4468)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4468.50 50 µg - - -

9 - 20 Werktage*

524,00 €
 
Recombinant Rat LAG3/CD223 Protein (His Tag) from Assay Genie. Recombinant Rat LAG3/CD223 Protein... mehr
Produktinformationen "Recombinant Rat LAG3/CD223 Protein (His Tag) (RPES4468)"
Recombinant Rat LAG3/CD223 Protein (His Tag) from Assay Genie. Recombinant Rat LAG3/CD223 Protein (His Tag) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II), the precise role of MHC-II-binding is however unclear. [The UniProt Consortium]
Schlagworte: Lag3
Hersteller: Assay Genie
Hersteller-Nr: RPES4468

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Format: Highly Purified

Datenbank Information

KEGG ID : K06565 | Passende Produkte
UniProt ID : Q5BK54 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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