Recombinant Rat IL0/Interleukin0 Protein (Active) (RPES3847)

Recombinant Rat IL0/Interleukin0 Protein (Active) (RPES3847)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3847.10 10 µg - - -

9 - 20 Werktage*

254,00 €
 
Recombinant Rat IL0/Interleukin0 Protein (Active) from Assay Genie. Recombinant Rat... mehr
Produktinformationen "Recombinant Rat IL0/Interleukin0 Protein (Active) (RPES3847)"
Recombinant Rat IL0/Interleukin0 Protein (Active) from Assay Genie. Recombinant Rat IL0/Interleukin0 Protein (Active) is a highly purified recombinant protein produced in E.coli and for the use in functional assays from Assay Genie.. Protein function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. [The UniProt Consortium]
Schlagworte: Il10, CSIF, Il-10, IL-10, Interleukin-10, Cytokine synthesis inhibitory factor
Hersteller: Assay Genie
Hersteller-Nr: RPES3847

Eigenschaften

Konjugat: No
Exprimiert in: E.coli
Format: Highly Purified

Datenbank Information

KEGG ID : K05443 | Passende Produkte
UniProt ID : P29456 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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