Recombinant Mouse TrkB/NTRK2 Protein (His Tag)(Active) (RPES3677)

Recombinant Mouse TrkB/NTRK2 Protein (His Tag)(Active) (RPES3677)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3677.20 20 µg - - -

9 - 20 Werktage*

422,00 €
Recombinant Mouse TrkB/NTRK2 Protein (His Tag)(Active) from Assay Genie. Recombinant Mouse... mehr
Produktinformationen "Recombinant Mouse TrkB/NTRK2 Protein (His Tag)(Active) (RPES3677)"
Recombinant Mouse TrkB/NTRK2 Protein (His Tag)(Active) from Assay Genie. Recombinant Mouse TrkB/NTRK2 Protein (His Tag)(Active) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. [The UniProt Consortium]
Schlagworte: Trk-B, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2
Hersteller: Assay Genie
Hersteller-Nr: RPES3677


Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Mouse
Format: Highly Purified

Datenbank Information

KEGG ID : K04360 | Passende Produkte
UniProt ID : P15209 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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