Recombinant Mouse NGAL/Lipocalin-2 Protein (His Tag)(Active) (RPES4534)

Recombinant Mouse NGAL/Lipocalin-2 Protein (His Tag)(Active) (RPES4534)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4534.50 50 µg - - -

9 - 20 Werktage*

524,00 €
 
Recombinant Mouse NGAL/Lipocalin-2 Protein (His Tag)(Active) from Assay Genie. Recombinant Mouse... mehr
Produktinformationen "Recombinant Mouse NGAL/Lipocalin-2 Protein (His Tag)(Active) (RPES4534)"
Recombinant Mouse NGAL/Lipocalin-2 Protein (His Tag)(Active) from Assay Genie. Recombinant Mouse NGAL/Lipocalin-2 Protein (His Tag)(Active) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:15531878, PubMed:16446425). Can also bind siderophores from M.tuberculosis. [The UniProt Consortium]
Schlagworte: p25, 24p3, NGAL, Lcn2, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, SV-40-induced 24p3 protein, Neutrophil gelatinase-associated lipocalin
Hersteller: Assay Genie
Hersteller-Nr: RPES4534

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Mouse
Format: Highly Purified

Datenbank Information

KEGG ID : K21129 | Passende Produkte
UniProt ID : P11672 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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