Recombinant Mouse NGAL/Lipocalin-2 Protein (His Tag)(Active) (RPES4534)

Recombinant Mouse NGAL/Lipocalin-2 Protein (His Tag)(Active) (RPES4534)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4534.50 50 µg - - -

9 - 20 Werktage*

1.015,00 €
 
Mouse NGAL/Lipocalin-2 Recombinant Protein (RPES4534) is a highly pure recombinant protein... mehr
Produktinformationen "Recombinant Mouse NGAL/Lipocalin-2 Protein (His Tag)(Active) (RPES4534)"
Mouse NGAL/Lipocalin-2 Recombinant Protein (RPES4534) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications Protein function: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:15531878, PubMed:16446425). Can also bind siderophores from M.tuberculosis. [The UniProt Consortium]
Schlagworte: p25, Lcn2, NGAL, 24p3, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, SV-40-induced 24p3 protein, Neutrophil gelatinase-associated lipocalin
Hersteller: Assay Genie
Hersteller-Nr: RPES4534

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: mouse
Format: Highly Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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