Recombinant Mouse HMGB1/HMG1 Protein (Fc Tag)(Active) (RPES3928)

Recombinant Mouse HMGB1/HMG1 Protein (Fc Tag)(Active) (RPES3928)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3928.10 10 µg - - -

9 - 20 Werktage*

465,00 €
 
Recombinant Mouse HMGB1/HMG1 Protein (Fc Tag)(Active) from Assay Genie. Recombinant Mouse... mehr
Produktinformationen "Recombinant Mouse HMGB1/HMG1 Protein (Fc Tag)(Active) (RPES3928)"
Recombinant Mouse HMGB1/HMG1 Protein (Fc Tag)(Active) from Assay Genie. Recombinant Mouse HMGB1/HMG1 Protein (Fc Tag)(Active) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity (PubMed:16365390). May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins. [The UniProt Consortium]
Schlagworte: HMG-1, Hmg-1, Hmgb1, High mobility group protein 1, High mobility group protein B1
Hersteller: Assay Genie
Hersteller-Nr: RPES3928

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Mouse
Format: Highly Purified

Datenbank Information

KEGG ID : K10802 | Passende Produkte
UniProt ID : P63158 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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