Recombinant Mouse FGFR4/CD334 Protein (His Tag) (RPES3972)

Recombinant Mouse FGFR4/CD334 Protein (His Tag) (RPES3972)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3972.50 50 µg - - -

9 - 20 Werktage*

562,00 €
 
Recombinant Mouse FGFR4/CD334 Protein (His Tag) from Assay Genie. Recombinant Mouse FGFR4/CD334... mehr
Produktinformationen "Recombinant Mouse FGFR4/CD334 Protein (His Tag) (RPES3972)"
Recombinant Mouse FGFR4/CD334 Protein (His Tag) from Assay Genie. Recombinant Mouse FGFR4/CD334 Protein (His Tag) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages. [The UniProt Consortium]
Schlagworte: Fgfr4, CD334, Fgfr-4, FGFR-4, EC=2.7.10.1, Fibroblast growth factor receptor 4, Protein-tyrosine kinase receptor MPK-11
Hersteller: Assay Genie
Hersteller-Nr: RPES3972

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Mouse
Format: Highly Purified

Datenbank Information

KEGG ID : K05095 | Passende Produkte
UniProt ID : Q03142 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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