Recombinant Mouse FGFR3 Protein (His Tag)(Active) (RPES4469)

Recombinant Mouse FGFR3 Protein (His Tag)(Active) (RPES4469)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4469.50 50 µg - - -

9 - 20 Werktage*

562,00 €
 
Recombinant Mouse FGFR3 Protein (His Tag)(Active) from Assay Genie. Recombinant Mouse FGFR3... mehr
Produktinformationen "Recombinant Mouse FGFR3 Protein (His Tag)(Active) (RPES4469)"
Recombinant Mouse FGFR3 Protein (His Tag)(Active) from Assay Genie. Recombinant Mouse FGFR3 Protein (His Tag)(Active) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of STAT1, STAT5A and STAT5B. Plays a role in postnatal lung development. [The UniProt Consortium]
Schlagworte: Mfr3, CD333, Fgfr3, FGFR-3, EC=2.7.10.1, Fibroblast growth factor receptor 3, Heparin-binding growth factor receptor
Hersteller: Assay Genie
Hersteller-Nr: RPES4469

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Mouse
Format: Highly Purified

Datenbank Information

UniProt ID : Q61851 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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