Recombinant Mouse CAMK4/CaMKIV Protein (His & GST Tag) (RPES4177)

Recombinant Mouse CAMK4/CaMKIV Protein (His & GST Tag) (RPES4177)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4177.20 20 µg - - -

9 - 20 Werktage*

422,00 €
 
Recombinant Mouse CAMK4/CaMKIV Protein (His & GST Tag) from Assay Genie. Recombinant Mouse... mehr
Produktinformationen "Recombinant Mouse CAMK4/CaMKIV Protein (His & GST Tag) (RPES4177)"
Recombinant Mouse CAMK4/CaMKIV Protein (His & GST Tag) from Assay Genie. Recombinant Mouse CAMK4/CaMKIV Protein (His & GST Tag) is a highly purified recombinant protein produced in Baculovirus-Insect Cells and for the use in functional assays from Assay Genie.. Protein function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. May be involved in spermatogenesis. [The UniProt Consortium]
Schlagworte: Camk4, CaMK IV, EC=2.7.11.17, CaM kinase-GR, Calcium/calmodulin-dependent protein kinase type IV
Hersteller: Assay Genie
Hersteller-Nr: RPES4177

Eigenschaften

Konjugat: No
Exprimiert in: Insect cells
Ursprungsart: Mouse
Format: Highly Purified

Datenbank Information

UniProt ID : P08414 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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