Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag) (RPES3577)

Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag) (RPES3577)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3577.10 10 µg - - -

9 - 20 Werktage*

379,00 €
 
Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag) from Assay Genie.... mehr
Produktinformationen "Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag) (RPES3577)"
Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag) from Assay Genie. Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag) is a highly purified recombinant protein produced in Human Cells and for the use in functional assays from Assay Genie.. Protein function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)- mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. [The UniProt Consortium]
Schlagworte: PC9, PCSK9, EC=3.4.21.-, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Proprotein convertase subtilisin/kexin type 9
Hersteller: Assay Genie
Hersteller-Nr: RPES3577

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Format: Highly Purified

Datenbank Information

UniProt ID : A8T662 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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