Recombinant Human TNF-alpha/TNFA Protein (Active) (RPES4122)

Recombinant Human TNF-alpha/TNFA Protein (Active) (RPES4122)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4122.10 10 µg - - -

9 - 20 Werktage*

85,00 €
 
Recombinant Human TNF-alpha/TNFA Protein (Active) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human TNF-alpha/TNFA Protein (Active) (RPES4122)"
Recombinant Human TNF-alpha/TNFA Protein (Active) from Assay Genie. Recombinant Human TNF-alpha/TNFA Protein (Active) is a highly purified recombinant protein produced in E.coli and for the use in functional assays from Assay Genie.. Protein function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T- cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819). [The UniProt Consortium]
Schlagworte: TNF, TNFA
Hersteller: Assay Genie
Hersteller-Nr: RPES4122

Eigenschaften

Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K03156 | Passende Produkte
UniProt ID : P01375 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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