Recombinant Human SUV420H2 Protein (His & GST Tag) (RPES4414)

Recombinant Human SUV420H2 Protein (His & GST Tag) (RPES4414)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4414.20 20 µg - - -

9 - 20 Werktage*

422,00 €
 
Recombinant Human SUV420H2 Protein (His & GST Tag) from Assay Genie. Recombinant Human SUV420H2... mehr
Produktinformationen "Recombinant Human SUV420H2 Protein (His & GST Tag) (RPES4414)"
Recombinant Human SUV420H2 Protein (His & GST Tag) from Assay Genie. Recombinant Human SUV420H2 Protein (His & GST Tag) is a highly purified recombinant protein produced in E.coli and for the use in functional assays from Assay Genie.. Protein function: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. [The UniProt Consortium]
Schlagworte: PP7130, SUV420H2, Suv4-20h2, Su(var)4-20 homolog 2, Lysine N-methyltransferase 5C, Lysine-specific methyltransferase 5C, Histone-lysine N-methyltransferase KMT5C, Suppressor of variegation 4-20 homolog 2, [histone H4]-lysine20 N-methyltransferase KMT5B
Hersteller: Assay Genie
Hersteller-Nr: RPES4414

Eigenschaften

Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K11429 | Passende Produkte
UniProt ID : Q86Y97 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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