Recombinant Human RGMA Protein (HEK293 Cells, His Tag) (RPES3728)

Recombinant Human RGMA Protein (HEK293 Cells, His Tag) (RPES3728)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3728.50 50 µg - - -

9 - 20 Werktage*

524,00 €
 
Recombinant Human RGMA Protein (HEK293 Cells, His Tag) from Assay Genie. Recombinant Human RGMA... mehr
Produktinformationen "Recombinant Human RGMA Protein (HEK293 Cells, His Tag) (RPES3728)"
Recombinant Human RGMA Protein (HEK293 Cells, His Tag) from Assay Genie. Recombinant Human RGMA Protein (HEK293 Cells, His Tag) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1- AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. [The UniProt Consortium]
Schlagworte: RGM, RGMA, RGM domain family member A, Repulsive guidance molecule A
Hersteller: Assay Genie
Hersteller-Nr: RPES3728

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K23096 | Passende Produkte
UniProt ID : Q96B86 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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