Recombinant Human RANKL/TNFSF11 Protein (His Tag)(Active) (RPES3610)

Recombinant Human RANKL/TNFSF11 Protein (His Tag)(Active) (RPES3610)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3610.10 10 µg - - -

9 - 20 Werktage*

206,00 €
 
Recombinant Human RANKL/TNFSF11 Protein (His Tag)(Active) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human RANKL/TNFSF11 Protein (His Tag)(Active) (RPES3610)"
Recombinant Human RANKL/TNFSF11 Protein (His Tag)(Active) from Assay Genie. Recombinant Human RANKL/TNFSF11 Protein (His Tag)(Active) is a highly purified recombinant protein produced in E.coli and for the use in functional assays from Assay Genie.. Protein function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation. [The UniProt Consortium]
Schlagworte: OPGL, TNFSF11
Hersteller: Assay Genie
Hersteller-Nr: RPES3610

Eigenschaften

Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K05473 | Passende Produkte
UniProt ID : O14788 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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