Recombinant Human R-Spondin 1/RSPO1 Protein (His Tag)(Active) (RPES3999)

Recombinant Human R-Spondin 1/RSPO1 Protein (His Tag)(Active) (RPES3999)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3999.10 10 µg - - -

9 - 20 Werktage*

149,00 €
 
Recombinant Human R-Spondin 1/RSPO1 Protein (His Tag)(Active) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human R-Spondin 1/RSPO1 Protein (His Tag)(Active) (RPES3999)"
Recombinant Human R-Spondin 1/RSPO1 Protein (His Tag)(Active) from Assay Genie. Recombinant Human R-Spondin 1/RSPO1 Protein (His Tag)(Active) is a highly purified recombinant protein produced in Human Cells and for the use in functional assays from Assay Genie.. Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin- dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1- mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805). [The UniProt Consortium]
Schlagworte: RSPO1, hRspo1, R-spondin-1, Roof plate-specific spondin-1
Hersteller: Assay Genie
Hersteller-Nr: RPES3999

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K19471 | Passende Produkte
UniProt ID : Q2MKA7 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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