Recombinant Human OTUB1 / OTB1 Protein (His tag)

Recombinant Human OTUB1 / OTB1 Protein (His tag)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH030767.100 100 µg -

7 - 16 Werktage*

475,00 €
 
Protein function: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin... mehr
Produktinformationen "Recombinant Human OTUB1 / OTB1 Protein (His tag)"
Protein function: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys- 48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin. [The UniProt Consortium]
Hersteller: Elabscience
Hersteller-Nr: E-PKSH030767

Eigenschaften

Konjugat: No
Spezies-Reaktivität: human
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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