Recombinant Human MERTK/MER Protein (His Tag) (RPES3920)

Recombinant Human MERTK/MER Protein (His Tag) (RPES3920)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3920.10 10 µg - - -

9 - 20 Werktage*

206,00 €
 
Recombinant Human MERTK/MER Protein (His Tag) from Assay Genie. Recombinant Human MERTK/MER... mehr
Produktinformationen "Recombinant Human MERTK/MER Protein (His Tag) (RPES3920)"
Recombinant Human MERTK/MER Protein (His Tag) from Assay Genie. Recombinant Human MERTK/MER Protein (His Tag) is a highly purified recombinant protein produced in Human Cells and for the use in functional assays from Assay Genie.. Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. [The UniProt Consortium]
Schlagworte: MER, MERTK, EC=2.7.10.1, Proto-oncogene c-Mer, Tyrosine-protein kinase Mer, Receptor tyrosine kinase MerTK
Hersteller: Assay Genie
Hersteller-Nr: RPES3920

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K05117 | Passende Produkte
UniProt ID : Q12866 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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