Recombinant Human MANF/ARMET Protein (Fc Tag) (RPES3707)

Recombinant Human MANF/ARMET Protein (Fc Tag) (RPES3707)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3707.20 20 µg - - -

9 - 20 Werktage*

254,00 €
 
Recombinant Human MANF/ARMET Protein (Fc Tag) from Assay Genie. Recombinant Human MANF/ARMET... mehr
Produktinformationen "Recombinant Human MANF/ARMET Protein (Fc Tag) (RPES3707)"
Recombinant Human MANF/ARMET Protein (Fc Tag) from Assay Genie. Recombinant Human MANF/ARMET Protein (Fc Tag) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PubMed:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PubMed:18561914, PubMed:22637475, PubMed:29497057). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PubMed:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions (PubMed:29497057). [The UniProt Consortium]
Schlagworte: MANF, ARMET, Protein ARMET, Arginine-rich protein, Mesencephalic astrocyte-derived neurotrophic factor
Hersteller: Assay Genie
Hersteller-Nr: RPES3707

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K22556 | Passende Produkte
UniProt ID : P55145 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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