Recombinant Human LR3-IGF Protein (MG)(Active) (RPES3738)

Recombinant Human LR3-IGF Protein (MG)(Active) (RPES3738)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3738.10 10 µg - - -

9 - 20 Werktage*

36,00 €
 
Recombinant Human LR3-IGF Protein (MG)(Active) from Assay Genie. Recombinant Human LR3-IGF... mehr
Produktinformationen "Recombinant Human LR3-IGF Protein (MG)(Active) (RPES3738)"
Recombinant Human LR3-IGF Protein (MG)(Active) from Assay Genie. Recombinant Human LR3-IGF Protein (MG)(Active) is a highly purified recombinant protein produced in E.coli and for the use in functional assays from Assay Genie.. Protein function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309). [The UniProt Consortium]
Schlagworte: MGF, IBP1, IGF1, IGF-I, Somatomedin-C, Mechano growth factor, Insulin-like growth factor I
Hersteller: Assay Genie
Hersteller-Nr: RPES3738

Eigenschaften

Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K05459 | Passende Produkte
UniProt ID : P05019 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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