Recombinant Human LEPR/CD295 Protein (His Tag)(Active) (RPES4437)

Recombinant Human LEPR/CD295 Protein (His Tag)(Active) (RPES4437)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4437.100 100 µg - - -

9 - 20 Werktage*

524,00 €
 
Recombinant Human LEPR/CD295 Protein (His Tag)(Active) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human LEPR/CD295 Protein (His Tag)(Active) (RPES4437)"
Recombinant Human LEPR/CD295 Protein (His Tag)(Active) from Assay Genie. Recombinant Human LEPR/CD295 Protein (His Tag)(Active) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite- regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production. [The UniProt Consortium]
Schlagworte: DB, OB-R, LEPR, LEP-R, CD295, HuB219, OB receptor, Leptin receptor
Hersteller: Assay Genie
Hersteller-Nr: RPES4437

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K05062 | Passende Produkte
UniProt ID : P48357 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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