Recombinant Human IL1F6/IL36A Protein (His Tag) (RPES3627)

Recombinant Human IL1F6/IL36A Protein (His Tag) (RPES3627)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3627.10 10 µg - - -

9 - 20 Werktage*

419,00 €
 
Recombinant Human IL1F6/IL36A Protein (His Tag) from Assay Genie. Recombinant Human IL1F6/IL36A... mehr
Produktinformationen "Recombinant Human IL1F6/IL36A Protein (His Tag) (RPES3627)"
Recombinant Human IL1F6/IL36A Protein (His Tag) from Assay Genie. Recombinant Human IL1F6/IL36A Protein (His Tag) is a highly purified recombinant protein produced in E.coli and for the use in functional assays from Assay Genie.. Protein function: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL- 36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung. [The UniProt Consortium]
Schlagworte: FIL1E, IL-1F6, IL-1 epsilon, FIL1 epsilon, Interleukin-36 alpha, Interleukin-1 epsilon, Interleukin-1 family member 6
Hersteller: Assay Genie
Hersteller-Nr: RPES3627

Eigenschaften

Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K05484 | Passende Produkte
UniProt ID : Q9UHA7 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier folgen Informationen zur Produktreferenz. mehr
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Recombinant Human IL1F6/IL36A Protein (His Tag) (RPES3627)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen