Recombinant Human HVEM/TNFRSF14 Protein (Fc Tag) (RPES4050)

Recombinant Human HVEM/TNFRSF14 Protein (Fc Tag) (RPES4050)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4050.10 10 µg - - -

9 - 20 Werktage*

100,00 €
 
Recombinant Human HVEM/TNFRSF14 Protein (Fc Tag) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human HVEM/TNFRSF14 Protein (Fc Tag) (RPES4050)"
Recombinant Human HVEM/TNFRSF14 Protein (Fc Tag) from Assay Genie. Recombinant Human HVEM/TNFRSF14 Protein (Fc Tag) is a highly purified recombinant protein produced in Human Cells and for the use in functional assays from Assay Genie.. Protein function: Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines. Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044). [The UniProt Consortium]
Schlagworte: TR2, HveA, HVEA, CD270, Herpesvirus entry mediator A, Herpes virus entry mediator A, Tumor necrosis factor receptor-like 2, Tumor necrosis factor receptor superfamily member 14
Hersteller: Assay Genie
Hersteller-Nr: RPES4050

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K05152 | Passende Produkte
UniProt ID : Q92956 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier folgen Informationen zur Produktreferenz. mehr
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Recombinant Human HVEM/TNFRSF14 Protein (Fc Tag) (RPES4050)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen