Recombinant Human Fibroblast Growth Factor 19/FGF-19 (N-6His)

Recombinant Human Fibroblast Growth Factor 19/FGF-19 (N-6His)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-32-8267-10 10 µg - -

2 - 11 Werktage

424,00 €
ABE-32-8267-50 50 µg - -

2 - 11 Werktage

704,00 €
 
Source: E. coli. MW :23.5kD. Recombinant Human Fibroblast growth factor 19 is produced by our... mehr
Produktinformationen "Recombinant Human Fibroblast Growth Factor 19/FGF-19 (N-6His)"
Source: E. coli. MW :23.5kD. Recombinant Human Fibroblast growth factor 19 is produced by our E.coli expression system and the target gene encoding Phe27-Lys216 is expressed with a 6His tag at the N-terminus. Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF19 can be considered as a regulator of energy expenditure. Protein function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. [The UniProt Consortium]
Hersteller: Abeomics
Hersteller-Nr: 32-8267

Eigenschaften

Konjugat: No

Handhabung & Sicherheit

Lagerung: +20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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