Recombinant Human FGFR1/CD331 Protein (His & Fc Tag)(Active) (RPES3606)

Recombinant Human FGFR1/CD331 Protein (His & Fc Tag)(Active) (RPES3606)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3606.50 50 µg - - -

9 - 20 Werktage*

524,00 €
 
Recombinant Human FGFR1/CD331 Protein (His & Fc Tag)(Active) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human FGFR1/CD331 Protein (His & Fc Tag)(Active) (RPES3606)"
Recombinant Human FGFR1/CD331 Protein (His & Fc Tag)(Active) from Assay Genie. Recombinant Human FGFR1/CD331 Protein (His & Fc Tag)(Active) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. [The UniProt Consortium]
Schlagworte: BFGFR, N-sam, FLT-2, FGFR1, CD331, FGFR-1, bFGF-R-1, Proto-oncogene c-Fgr, Fms-like tyrosine kinase 2, Fibroblast growth factor receptor 1, Basic fibroblast growth factor receptor 1
Hersteller: Assay Genie
Hersteller-Nr: RPES3606

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K04362 | Passende Produkte
UniProt ID : P11362 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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