Recombinant Human DR6/TNFRSF21 Protein (His Tag) (RPES4410)

Recombinant Human DR6/TNFRSF21 Protein (His Tag) (RPES4410)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4410.10 10 µg - - -

9 - 20 Werktage*

57,00 €
 
Recombinant Human DR6/TNFRSF21 Protein (His Tag) from Assay Genie. Recombinant Human DR6/TNFRSF21... mehr
Produktinformationen "Recombinant Human DR6/TNFRSF21 Protein (His Tag) (RPES4410)"
Recombinant Human DR6/TNFRSF21 Protein (His Tag) from Assay Genie. Recombinant Human DR6/TNFRSF21 Protein (His Tag) is a highly purified recombinant protein produced in Human Cells and for the use in functional assays from Assay Genie.. Protein function: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP- beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21, this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. [The UniProt Consortium]
Schlagworte: DR6, CD358, TNFRSF21, Death receptor 6, Tumor necrosis factor receptor superfamily member 21
Hersteller: Assay Genie
Hersteller-Nr: RPES4410

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K05157 | Passende Produkte
UniProt ID : O75509 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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