Recombinant Human Cyclophilin A Protein (RPES3919)

Recombinant Human Cyclophilin A Protein (RPES3919)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3919.10 10 µg - - -

9 - 20 Werktage*

215,00 €
Recombinant Human Cyclophilin A Protein from Assay Genie. Recombinant Human Cyclophilin A Protein... mehr
Produktinformationen "Recombinant Human Cyclophilin A Protein (RPES3919)"
Recombinant Human Cyclophilin A Protein from Assay Genie. Recombinant Human Cyclophilin A Protein is a highly purified recombinant protein produced in E.coli and for the use in functional assays from Assay Genie.. Protein function: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:25678563, PubMed:21593166). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation. Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton. Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:30328013, PubMed:22347431). [The UniProt Consortium]
Schlagworte: CYPA, PPIA
Hersteller: Assay Genie
Hersteller-Nr: RPES3919


Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K03767 | Passende Produkte
UniProt ID : P62937 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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