Recombinant Human cIAP1/HIAP2 Protein (AVI Tag)(Active) (RPES3687)

Recombinant Human cIAP1/HIAP2 Protein (AVI Tag)(Active) (RPES3687)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3687.50 50 µg - - -

9 - 20 Werktage*

524,00 €
 
Recombinant Human cIAP1/HIAP2 Protein (AVI Tag)(Active) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human cIAP1/HIAP2 Protein (AVI Tag)(Active) (RPES3687)"
Recombinant Human cIAP1/HIAP2 Protein (AVI Tag)(Active) from Assay Genie. Recombinant Human cIAP1/HIAP2 Protein (AVI Tag)(Active) is a highly purified recombinant protein produced in E.coli and for the use in functional assays from Assay Genie.. Protein function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. [The UniProt Consortium]
Schlagworte: API1, hIAP2, BIRC2, C-IAP1, hIAP-2, IAP homolog B, RING finger protein 48, Inhibitor of apoptosis protein 2, Cellular inhibitor of apoptosis 1, TNFR2-TRAF-signaling complex protein 2, RING-type E3 ubiquitin transferase BIRC2
Hersteller: Assay Genie
Hersteller-Nr: RPES3687

Eigenschaften

Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K16060 | Passende Produkte
UniProt ID : Q13490 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier folgen Informationen zur Produktreferenz. mehr
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Recombinant Human cIAP1/HIAP2 Protein (AVI Tag)(Active) (RPES3687)"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen