Recombinant Human CD8A/MAL Protein (His Tag)(Active) (RPES4646)

Recombinant Human CD8A/MAL Protein (His Tag)(Active) (RPES4646)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4646.10 10 µg - - -

9 - 20 Werktage*

562,00 €
 
Recombinant Human CD8A/MAL Protein (His Tag)(Active) from Assay Genie. Recombinant Human CD8A/MAL... mehr
Produktinformationen "Recombinant Human CD8A/MAL Protein (His Tag)(Active) (RPES4646)"
Recombinant Human CD8A/MAL Protein (His Tag)(Active) from Assay Genie. Recombinant Human CD8A/MAL Protein (His Tag)(Active) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T- lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. [The UniProt Consortium]
Schlagworte: MAL, CD8a, CD8A, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2
Hersteller: Assay Genie
Hersteller-Nr: RPES4646

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K06458 | Passende Produkte
UniProt ID : P01732 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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