Recombinant Human CD86/B7-2 Protein (Val185Ile, His Tag)(Active) (RPES3596)

Human CD86/B7-2 Recombinant Protein (RPES3596) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications Protein function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. [The UniProt Consortium]