Recombinant Human CD3d/CD3 delta Protein (Fc&FLAG Tag) (RPES4605)

Recombinant Human CD3d/CD3 delta Protein (Fc&FLAG Tag) (RPES4605)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4605.20 20 µg - - -

9 - 20 Werktage*

422,00 €
 
Recombinant Human CD3d/CD3 delta Protein (Fc&FLAG Tag) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human CD3d/CD3 delta Protein (Fc&FLAG Tag) (RPES4605)"
Recombinant Human CD3d/CD3 delta Protein (Fc&FLAG Tag) from Assay Genie. Recombinant Human CD3d/CD3 delta Protein (Fc&FLAG Tag) is a highly purified recombinant protein produced in HEK293 Cells and for the use in functional assays from Assay Genie.. Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456). [The UniProt Consortium]
Schlagworte: T3D, CD3D, CD3d, T-cell receptor T3 delta chain, T-cell surface glycoprotein CD3 delta chain
Hersteller: Assay Genie
Hersteller-Nr: RPES4605

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K06450 | Passende Produkte
UniProt ID : P04234 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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