Recombinant Human Cbl-c/CBL-3 Protein (His & GST Tag) (RPES3619)

Recombinant Human Cbl-c/CBL-3 Protein (His & GST Tag) (RPES3619)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES3619.20 20 µg - - -

9 - 20 Werktage*

422,00 €
 
Recombinant Human Cbl-c/CBL-3 Protein (His & GST Tag) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human Cbl-c/CBL-3 Protein (His & GST Tag) (RPES3619)"
Recombinant Human Cbl-c/CBL-3 Protein (His & GST Tag) from Assay Genie. Recombinant Human Cbl-c/CBL-3 Protein (His & GST Tag) is a highly purified recombinant protein produced in Baculovirus-Insect Cells and for the use in functional assays from Assay Genie.. Protein function: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival. [The UniProt Consortium]
Schlagworte: CBLC, CBL3, RING finger protein 57, SH3-binding protein CBL-3, SH3-binding protein CBL-C, Signal transduction protein CBL-C, E3 ubiquitin-protein ligase CBL-C, RING-type E3 ubiquitin transferase CBL-C
Hersteller: Assay Genie
Hersteller-Nr: RPES3619

Eigenschaften

Konjugat: No
Exprimiert in: Insect cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K22518 | Passende Produkte
UniProt ID : Q9ULV8 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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