Recombinant Human CAMK1/CaMKI-alpha Protein (His Tag) (RPES4007)

Recombinant Human CAMK1/CaMKI-alpha Protein (His Tag) (RPES4007)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-RPES4007.10 10 µg - - -

9 - 20 Werktage*

149,00 €
 
Recombinant Human CAMK1/CaMKI-alpha Protein (His Tag) from Assay Genie. Recombinant Human... mehr
Produktinformationen "Recombinant Human CAMK1/CaMKI-alpha Protein (His Tag) (RPES4007)"
Recombinant Human CAMK1/CaMKI-alpha Protein (His Tag) from Assay Genie. Recombinant Human CAMK1/CaMKI-alpha Protein (His Tag) is a highly purified recombinant protein produced in Human Cells and for the use in functional assays from Assay Genie.. Protein function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser- 92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. [The UniProt Consortium]
Schlagworte: CAMK1, CaM-KI, CaMKI-alpha, CaM kinase I, EC=2.7.11.17, CaM kinase I alpha, Calcium/calmodulin-dependent protein kinase type 1
Hersteller: Assay Genie
Hersteller-Nr: RPES4007

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
Format: Highly Purified

Datenbank Information

KEGG ID : K08794 | Passende Produkte
UniProt ID : Q14012 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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