Receptor Tyrosine-Protein Kinase ErbB-3/HER3 (C-6His) (recombinant human)

Receptor Tyrosine-Protein Kinase ErbB-3/HER3 (C-6His) (recombinant human)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH033900.10 10 µg -

7 - 16 Werktage*

111,00 €
E-PKSH033900.50 50 µg -

7 - 16 Werktage*

329,00 €
 
Protein Construction: Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-3 is produced by... mehr
Produktinformationen "Receptor Tyrosine-Protein Kinase ErbB-3/HER3 (C-6His) (recombinant human)"
Protein Construction: Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-3 is produced by our Mammalian expression system and the target gene encoding Ser20-Thr643 is expressed with a 6His tag at the C-terminus. Sequence: Ser20-Thr643. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 90-100 kDa. Protein function: Receptor tyrosine-protein kinase erbB-3 is an enzyme that in humans is encoded by the ERBB3 gene. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB3 belongs to the protein kinase superfamily,tyr protein kinase family and EGF receptor subfamily.It contains 1 protein kinase domain and it is expressed in Epithelial tissues and brain. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Protein function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). [The UniProt Consortium]
Schlagworte: HER3, ERBB3, EC=2.7.10.1, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-3/HER3 (C-6His)
Hersteller: Elabscience
Hersteller-Nr: E-PKSH033900

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: human
MW: 69.5 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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