Polymerase Cofactor VP35, Recombinant, Zaire Ebolavirus, aa1-340, His-Tag, Myc-Tag (VP35)

Polymerase Cofactor VP35, Recombinant, Zaire Ebolavirus, aa1-340, His-Tag, Myc-Tag (VP35)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
406024.20 20 µg - -

3 - 19 Werktage*

511,00 €
406024.100 100 µg - -

3 - 19 Werktage*

818,00 €
 
Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex.... mehr
Produktinformationen "Polymerase Cofactor VP35, Recombinant, Zaire Ebolavirus, aa1-340, His-Tag, Myc-Tag (VP35)"
Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR. Source: Recombinant protein corresponding to aa1-340 from Zaire ebolavirus Polymerase Cofactor VP35, fused to His-tag at N-terminal and fused to Myc-tag at C-terminal, expressed in E. coli. Molecular Weight: ~42.4kD, AA Sequence: MTTRTKGRGHTAATTQNDRMPGPELSGWISEQLMTGRIPVSDIFCDIENNPGLCYASQMQQTKPNPKTRNSQTQTDPICNHSFEEVVQTLASLATVVQQQTIASESLEQRITSLENGLKPVYDMAKTISSLNRVCAEMVAKYDLLVMTTGRATATAAATEAYWAEHGQPPPGPSLYEESAIRGKIESRDETVPQSVREAFNNLDSTTSLTEENFGKPDISAKDLRNIMYDHLPGFGTAFHQLVQVICKLGKDSNSLDIIHAEFQASLAEGDSPQCALIQITKRVPIFQDAAPPVIHIRSRGDIPRACQKSLRPVPPSPKIDRGWVCVFQLQDGKTLGLKI, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: VP35, eVP35, Ebola VP35, Polymerase cofactor VP35
Hersteller: United States Biological
Hersteller-Nr: 406024

Eigenschaften

Konjugat: No
MW: 42,4
Format: Purified

Datenbank Information

UniProt ID : Q6V1Q9 | Passende Produkte

Handhabung & Sicherheit

Lagerung: °C
Versand: °C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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