PCSK9/NARC1 Protein (His Tag) (recombinant mouse)

PCSK9/NARC1 Protein (His Tag) (recombinant mouse)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSM041128.10 10 µg -

7 - 16 Werktage*

265,00 €
E-PKSM041128.50 50 µg -

7 - 16 Werktage*

705,00 €
 
Protein Construction: Recombinant Mouse Proprotein Convertase Subtilisin/Kexin Type 9 is produced... mehr
Produktinformationen "PCSK9/NARC1 Protein (His Tag) (recombinant mouse)"
Protein Construction: Recombinant Mouse Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln35-Gln155&Ser156-Gln692 is expressed with a 6His tag at the C-terminus. Sequence: Gln35-Gln155&Ser156-Gln692. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 19&60 kDa. Protein function: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis.PCSK9 also plays a role in neural development. Protein function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)- mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. [The UniProt Consortium]
Schlagworte: PC9, Narc1, Pcsk9, NARC-1, EC=3.4.21.-, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, Proprotein convertase subtilisin/kexin type 9, Recombinant Mouse PCSK9/NARC1 Protein (His Tag)
Hersteller: Elabscience
Hersteller-Nr: E-PKSM041128

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: mouse
MW: 14 kD
Format: Solution

Handhabung & Sicherheit

Lagerung: -80°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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