PCSK9 / NARC1 Protein (His tag) (recombinant mouse)

PCSK9 / NARC1 Protein (His tag) (recombinant mouse)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSM040778.20 20 µg -

7 - 16 Werktage*

341,00 €
E-PKSM040778.100 100 µg -

7 - 16 Werktage*

1.210,00 €
 
Activity: Measured by its binding ability in a functional ELISA. Immobilized mouse PCSK9 at 10... mehr
Produktinformationen "PCSK9 / NARC1 Protein (His tag) (recombinant mouse)"
Activity: Measured by its binding ability in a functional ELISA. Immobilized mouse PCSK9 at 10 µg/ml (100 µl/well) can bind biotinylated recombinant human LDLR. The EC50 of biotinylated human LDLR is 0.12 µg/ml. Protein Construction: A DNA sequence encoding the full length of mouse PCSK9 (NP_705793.1) precursor (Met 1-Gln 694) was expressed, with a C-terminal polyhistidine tag. Sequence: Met 1-Gln 694. Fusion tag: C-His Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method. Apparent Molecular Mass: 19 & 65 kDa. Protein function: Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons. References Protein function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. [The UniProt Consortium]
Schlagworte: PC9, Pcsk9, Narc1, NARC-1, EC=3.4.21.-, Proprotein convertase 9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, Proprotein convertase subtilisin/kexin type 9, Recombinant Mouse PCSK9 / NARC1 Protein (His tag)
Hersteller: Elabscience
Hersteller-Nr: E-PKSM040778

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: mouse
MW: 72.6 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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