NK3 Homeobox 1 (human recombinant)

NK3 Homeobox 1 (human recombinant)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-32-4326-20 20 µg - -

3 - 11 Werktage*

554,00 €
 
Source : Escherichia Coli. NKX3-1 Human Recombinant produced in E.Coli is a single,... mehr
Produktinformationen "NK3 Homeobox 1 (human recombinant)"
Source : Escherichia Coli. NKX3-1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 257 amino acids (1-234 a.a) and having a molecular mass of 28.7kDa.NKX3-1 is fused to a 23 amino acid His-tag at N-terminus , purified by proprietary chromatographic techniques. NK3 Homeobox1 (NKX3-1) is a homeobox-containing transcription factor, which binds preferentially the consensus sequence 5,-TAAGT[AG]-3, and may act as a transcriptional repressor. The NKX3-1 transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. NKX3-1 has an imperative role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. In addition, NKX3-1 functions as a tumor suppressor controlling prostate carcinogenesis, as shown by its ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Abnormal expression of NKX3-1 is linked with prostate tumor progression. Protein function: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. [The UniProt Consortium]
Schlagworte: NKX3-1, NKX3.1, Homeobox protein Nkx-3.1, Homeobox protein NK-3 homolog A
Hersteller: Abeomics
Hersteller-Nr: 32-4326

Eigenschaften

Konjugat: No
Format: Solution

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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