MAPK8IP3 PrEST Antigen

MAPK8IP3 PrEST Antigen
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-APrEST88668.100 100 µl - -

7 - 10 Werktage*

247,00 €
 
Protein function: The JNK-interacting protein (JIP) group of scaffold proteins selectively... mehr
Produktinformationen "MAPK8IP3 PrEST Antigen"
Protein function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). [The UniProt Consortium] Buffer: PBS and 1M Urea, pH 7.4.
Schlagworte: JIP3, JIP-3, MAPK8IP3, JNK-interacting protein 3, JNK MAP kinase scaffold protein 3, C-Jun-amino-terminal kinase-interacting protein 3, Mitogen-activated protein kinase 8-interacting protein 3
Hersteller: Atlas Antibodies
Hersteller-Nr: APrEST88668

Eigenschaften

Anwendung: Control antigen
Konjugat: No
Wirt: E.coli
Spezies-Reaktivität: human

Handhabung & Sicherheit

Lagerung: -20°C (avoid repeat freezing and thawing cycles)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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