ICOS/AILIM Protein (Fc Tag) (recombinant human)

ICOS/AILIM Protein (Fc Tag) (recombinant human)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH033644.10 10 µg -

7 - 16 Werktage*

139,00 €
E-PKSH033644.50 50 µg -

7 - 16 Werktage*

352,00 €
 
Protein Construction: Recombinant Human ICOS is produced by our Mammalian expression system and... mehr
Produktinformationen "ICOS/AILIM Protein (Fc Tag) (recombinant human)"
Protein Construction: Recombinant Human ICOS is produced by our Mammalian expression system and the target gene encoding Glu21-Phe141 is expressed with a Fc tag at the C-terminus. Sequence: Glu21-Phe141. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 47 kDa. Protein function: Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige Protein function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching of immunoglobin isotypes. [The UniProt Consortium]
Schlagworte: ICOS, CD278, AILIM, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, Recombinant Human ICOS/AILIM Protein (Fc Tag)
Hersteller: Elabscience
Hersteller-Nr: E-PKSH033644

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: human
MW: 408 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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