GLS1, active human recombinant protein, His-tag

Human glutaminase (GLS), also known as glutaminase transcript variant 1 (GLS1), GAC, GAM and KGA, GenBank Accession No. NM_014905, a.a. 17-669(end), with N-terminal His-tag, MW 72.5, expressed in an E. coli cell expression system. Protein function: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. [The UniProt Consortium]