Galectin-3/LGALS3 Protein (recombinant human)

Galectin-3/LGALS3 Protein (recombinant human)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH032474.10 10 µg - -

7 - 16 Werktage

68,00 €
E-PKSH032474.50 50 µg - -

7 - 16 Werktage

184,00 €
Activity: Measured by its ability to agglutinate human red blood cells.Activated Protein... mehr
Produktinformationen "Galectin-3/LGALS3 Protein (recombinant human)"
Activity: Measured by its ability to agglutinate human red blood cells.Activated Protein Construction: Recombinant Human Galectin-3 is produced by our E.coli expression system and the target gene encoding Ala2-Ile250 is expressed. Sequence: Ala2-Ile250. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 30 kDa. Protein function: The Galectin family of proteins consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. They have diverse effects on many cellular functions including adhesion, migration, polarity, chemotaxis, proliferation, apoptosis, and differentiation. Galectins may therefore play a key role in many pathological states, including autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetic complications. The galectins have been classified into the prototype galectins (1, 2, 5, 7, 10, 11, 13, 14), which contain one CRD and exist either as a monomer or a noncovalent homodimer. The chimera galectins (Galectin3) containing one CRD linked to a nonlectin domain, and the tandem repeat Galectins (4, 6, 8, 9, 12) consisting of two CRDs joined by a linker Protein function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. [The UniProt Consortium]
Schlagworte: MAC2, L-31, GALBP, Gal-3, LGALS3, CBP 35, Galectin-3, Lectin L-29, Mac-2 antigen, 35 kDa lectin, IgE-binding protein, Laminin-binding protein, Galactoside-binding protein, Galactose-specific lectin 3, Carbohydrate-binding protein 35, Recombinant Human Gal
Hersteller: Elabscience
Hersteller-Nr: PKSH032474-10µg


Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
MW: 26.0 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: +20°C (International: +20°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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