Galectin-3/LGALS3 Protein(C-6His, Cells) (recombinant human)

Galectin-3/LGALS3 Protein(C-6His, Cells) (recombinant human)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH032473.10 10 µg - -

7 - 16 Werktage

123,00 €
E-PKSH032473.50 50 µg - -

7 - 16 Werktage

328,00 €
 
Protein Construction: Recombinant Human Galectin-3 is produced by our Mammalian expression system... mehr
Produktinformationen "Galectin-3/LGALS3 Protein(C-6His, Cells) (recombinant human)"
Protein Construction: Recombinant Human Galectin-3 is produced by our Mammalian expression system and the target gene encoding Ala2-Ile250 is expressed with a 6His tag at the C-terminus. Sequence: Ala2-Ile250. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 35 kDa. Protein function: Galectin-3(LGALS3) is also known as Galactose-specific lectin 3, Mac-2 antigen, Carbohydrate-binding protein 35, Laminin-binding protein and Galactoside-binding protein. LGALS3 is highly expressed in early stages of papillary carcinoma, and lowly during tumor progression. LGALS3 is probably forms homo- or heterodimers and secreted by a non-classical secretory pathway and associates with the cell surface. LGALS3 plays an important role during the acquisition of vasculogenic mimicry and angiogenic properties. LGLAS3 takes part in an immune regulator to inhibit T-cell immune responses and promote tumor growth, as a result providing a new mechanism for tumor immune tolerance. Protein function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. [The UniProt Consortium]
Schlagworte: MAC2, L-31, GALBP, Gal-3, LGALS3, CBP 35, Galectin-3, Lectin L-29, Mac-2 antigen, 35 kDa lectin, IgE-binding protein, Laminin-binding protein, Galactoside-binding protein, Galactose-specific lectin 3, Carbohydrate-binding protein 35, Recombinant Human Gal
Hersteller: Elabscience
Hersteller-Nr: PKSH032473-10µg

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human
MW: 27.2 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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