Folate Receptor alpha/FOLR1 (C-6His-Avi) Biotinylated (recombinant human)

Folate Receptor alpha/FOLR1 (C-6His-Avi) Biotinylated (recombinant human)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-PKSH033924.20 20 µg -

7 - 16 Werktage*

406,00 €
E-PKSH033924.100 100 µg -

7 - 16 Werktage*

1.097,00 €
 
Protein Construction: Biotinylated Recombinant Human Folate Receptor Alpha is produced by our... mehr
Produktinformationen "Folate Receptor alpha/FOLR1 (C-6His-Avi) Biotinylated (recombinant human)"
Protein Construction: Biotinylated Recombinant Human Folate Receptor Alpha is produced by our Mammalian expression system and the target gene encoding Arg25-Ser234 is expressed with a 6His, Avi tag at the C-terminus. Sequence: Arg25-Ser234. Fusion tag: C-6His-Avi Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 35-40 kDa. Protein function: Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation. Protein function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. [The UniProt Consortium]
Schlagworte: FBP, FOLR, FOLR1, FR-alpha, KB cells FBP, Folate receptor 1, Folate receptor alpha, Folate receptor, adult, Adult folate-binding protein, Ovarian tumor-associated antigen MOv18, Recombinant Human Folate Receptor alpha/FOLR1 (C-6His-Avi) Biotinylated
Hersteller: Elabscience
Hersteller-Nr: E-PKSH033924

Eigenschaften

Konjugat: Biotin
Wirt: Human cells
Spezies-Reaktivität: human
MW: 27.5 kD
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -80°C
Versand: 4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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