FABP4 (human recombinant) FITC conjugated

Fatty acid binding protein 4 (FABP4) is a member of the intracellular lipid-binding protein (iLBP) family. It is composed of a beta-barrel, which forms the lipid-binding site, and two alpha-helices that form a lid on the beta-barrel. FABP4 is primarily expressed in adipocytes but has also been found in activated macrophages. It is involved in lipid transport and metabolism, insulin resistance, and angiogenesis, and its expression is induced by long-chain fatty acids and peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. Knockout of Fabp4 prevents the development of atherosclerosis in ApoE-/- mice and increases body weight gain and insulin sensitivity in ob/ob mice. Serum levels of FABP4 are increased in patients with colorectal cancer, and serum and synovial fluid levels of FABP4 are increased in patients with rheumatoid arthritis. Cayman's FABP4 (human recombinant) FITC conjugated protein is conjugated to fluorescein isothiocyanate (FITC) and can be used for fluorescence applications.Synonyms: Adipocyte FABP, A-FABP, ALBP, aP2, Fatty Acid Binding Protein 4. Purity: >95% (estimated by SDS-PAGE). Source: Recombinant N-terminal His-tagged protein expressed in E. coli. Amino Acids: 1-132 (full-length). MW: 19 kDa. Formulation: (Request formulation change), 50 mM sodium phosphate, pH 7.2, with 100 mM sodium chloride and 20% glycerol.