E3 Ubiquitin-Protein Ligase TRAIP, Recombinant, Human, aa1-469, 6xHis-Tag (TRAIP)

E3 Ubiquitin-Protein Ligase TRAIP, Recombinant, Human, aa1-469, 6xHis-Tag (TRAIP)
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
517883.20 20 µg - -

3 - 19 Werktage*

455,00 €
517883.100 100 µg - -

3 - 19 Werktage*

713,00 €
 
E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits... mehr
Produktinformationen "E3 Ubiquitin-Protein Ligase TRAIP, Recombinant, Human, aa1-469, 6xHis-Tag (TRAIP)"
E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase. Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity. The function in translesion synthesis is controversial. Source: Recombinant full length protein corresponding to aa1-469 of human E3 Ubiquitin-Protein Ligase TRAIP, fused to 6xHis-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~58.8kD, AA Sequence: MPIRALCTICSDFFDHSRDVAAIHCGHTFHLQCLIQWFETAPSRTCPQCRIQVGKRTIINKLFFDLAQEEENVLDAEFLKNELDNVRAQLSQKDKEKRDSQVIIDTLRDTLEERNATVVSLQQALGKAEMLCSTLKKQMKYLEQQQDETKQAQEEARRLRSKMKTMEQIELLLQSQRPEVEEMIRDMGVGQSAVEQLAVYCVSLKKEYENLKEARKASGEVADKLRKDLFSSRSKLQTVYSELDQAKLELKSAQKDLQSADKEIMSLKKKLTMLQETLNLPPVASETVDRLVLESPAPVEVNLKLRRPSFRDDIDLNATFDVDTPPARPSSSQHGYYEKLCLEKSHSPIQDVPKKICKGPRKESQLSLGGQSCAGEPDEELVGAFPIFVRNAILGQKQPKRPRSESSCSKDVVRTGFDGLGGRTKFIQPTDTVMIRPLPVKPKTKVKQRVRVKTVPSLFQAKLDTFLWS, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: TRAIP, RNF206, EC=2.3.2.27, RING finger protein 206, TRAF-interacting protein, E3 ubiquitin-protein ligase TRAIP, RING-type E3 ubiquitin transferase TRAIP
Hersteller: United States Biological
Hersteller-Nr: 517883

Eigenschaften

Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
MW: 58.8 kD
Reinheit: ?85% (SDS-PAGE)

Handhabung & Sicherheit

Lagerung: °C
Versand: °C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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