CSPG4, Recombinant Human Protein with C-terminal 6xHis tag

CSPG4, Recombinant Human Protein with C-terminal 6xHis tag
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-32-17140-50 50 µg - -

3 - 11 Werktage*

635,00 €
ABE-32-17140-100 100 µg - -

3 - 11 Werktage*

756,00 €
 
Expression Host : HEK293. The protein has a predicted molecular mass of 237.7 kDa after removal... mehr
Produktinformationen "CSPG4, Recombinant Human Protein with C-terminal 6xHis tag"
Expression Host : HEK293. The protein has a predicted molecular mass of 237.7 kDa after removal of the signal peptide. A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. Protein function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. [The UniProt Consortium]
Schlagworte: MCSP, CSPG4, Chondroitin sulfate proteoglycan 4, Chondroitin sulfate proteoglycan NG2, Melanoma chondroitin sulfate proteoglycan, Melanoma-associated chondroitin sulfate proteoglycan, CSPG4A, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2, Recombinant Human C
Hersteller: Abeomics
Hersteller-Nr: 32-17140

Eigenschaften

Konjugat: No
Exprimiert in: Human cells
Ursprungsart: Human

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: °C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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