COX-1 (ovine)

COX-1 (ovine)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay60100-5 5 kU -

6 - 10 Werktage*

1.098,00 €
 
Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase... mehr
Produktinformationen "COX-1 (ovine)"
Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities. It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail. COX-1 is constitutively expressed in the gastrointestinal tract, kidney, spleen, liver, and lung and localizes to the endoplasmic reticulum. The COX component converts arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) to a hydroperoxyl endoperoxide prostaglandin G2 (PGG2, Cay-17010) and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Cay-17020), the precursor of PGs, thromboxanes, and prostacyclins. COX-1 is the target of many non-steroidal anti-inflammatory drugs (NSAIDs) and is responsible for the undesirable gastrointestinal and renal side effects, such as ulcer formation and reductions in the glomerular filtration rate, respectively. Cayman's COX-1 (ovine) protein can be used for enzyme activity assays.Synonyms: Cyclooxygenase 1, PGHS-1, Prostaglandin Endoperoxide Synthase 1, Prostaglandin G/H Synthase 1, Prostaglandin H2 Synthase 1. Protein Identity Confirmed by Mass Spec: Yes. Source: Active COX-1 isolated from ram seminal vesicles. Amino Acids: Full length. MW: 70 kDa. Formulation: (Request formulation change), 80 mM Tris-HCl, pH 8.0, containing 0.3 mM DDC, 0.1% polysorbate 20, and 10% glycerol. Enzyme Commission: 1.14.99.1. UniProt Accession #: P05979. Origin: Animal/Ram.
Schlagworte: COX1, PTGS1, COX-1, PHS 1, COX-1, PHS 1, PGHS-1, PGHS-1, PGH synthase 1, PGH synthase 1, Cyclooxygenase-1, Cyclooxygenase-1, Prostaglandin H2 synthase 1, Prostaglandin H2 synthase 1, Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 1, Prostaglandi
Hersteller: Cayman Chemical
Hersteller-Nr: 60100

Eigenschaften

Anwendung: Enzyme activity
Konjugat: No
Format: Solution

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -80°C (International: -80°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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