CD27 (human) (rec.) (His)

CD27 (human) (rec.) (His)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
CHI-HR-200CD27-C050 50 µg - -

3 - 9 Werktage*

380,00 €
 
Human CD27 (aa 21-192) is fused at the C-terminus to a His-tag. CD27 (TNFRSF7) is a member of the... mehr
Produktinformationen "CD27 (human) (rec.) (His)"
Human CD27 (aa 21-192) is fused at the C-terminus to a His-tag. CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-?B and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.
Schlagworte: T14, CD27, TNFRSF7, CD27 antigen, CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7
Hersteller: Chimerigen Laboratories
Hersteller-Nr: HR-200CD27

Eigenschaften

Anwendung: Bioassays
Konjugat: No
Wirt: E.coli
Spezies-Reaktivität: human
Reinheit: >97%
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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