Aprotinin, Bovine (US/North America)

Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins., Aprotinin is a natural proteinase inhibitor polypeptide consisting of 58 amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512D. Synonyms: Antikrein, Antilysin, Antilysine, Aprostat, Aprotinin, BPTI, BPTI Trypsin Inhibitor, Basic Pancreatic Trypsin Inhibitor, Bayer A 128, Bovine Basic Pancreatic Trypsin Inhibitor, Bovine Pancreatic Trypsin Inhibitor, Bovine Trypsin Inhibitor, Fosten, Kallikrein-trypsin Inactivator, Kiker 52G, Kir Richter, Kunitz Pancreatic Trypsin Inhibitor, Kunitz Protease Inhibitor, Kunitz Trypsin Inhibitor, Kunitz-type Inhibitor, Kunitz-type Proteinase Inhibitor, Kunitz-type Trypsin Inhibitor, Onquinin, Pancreatic Basic Trypsin Inhibitor, Pancreatic Trypsin Inhibitor, Pancreatic Trypsin Inhibitor (Kunitz), Protease Inhibitor, Kunitz Type, RP 9921, Repulson, Trasuylol, Trasylol, Trazinin, Triazinin, Trypsin Inhibitor, Trasylol, Trypsin-kallikrein Inhibitor (Kunitz), Zymofren, CAS No: 9087-70-1, Source: Bovine lung, Appearance: White or yellowish powder, Activity (dried basis): >5400KIU/mg, Histamine: <0.2ug/3EU, Absorbance: <0.8, Loss on Drying: <2%, Protein impurities of higher molecular mass: Complies, Bacterial Endotoxins: None Detected, Abnormal Toxicity: Non-toxic, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. Reconstitute with ddH2O. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.