ACE2 (mouse) (rec.)

ACE2 (mouse) (rec.)
%
COVID-19 Forschung
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Rabatt Preis
AG-40B-0193-C050 50 µg -

3 - 9 Werktage*

10 %
429,00 €
386,10 €
AG-40B-0193-3050 150 µg (3 x 50 µg) -

3 - 9 Werktage*

10 %
858,00 €
772,20 €
 
Extracellular domain of mouse ACE2 (aa 18-740) are fused at the C-terminus to a FLAG(R)-tag.... mehr
Produktinformationen "ACE2 (mouse) (rec.)"
Extracellular domain of mouse ACE2 (aa 18-740) are fused at the C-terminus to a FLAG(R)-tag. Protein function: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury. [The UniProt Consortium] Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.
Schlagworte: Ace2, EC=3.4.17.23, SARS-Receptor, Angiotensin-converting Enzyme 2, ACEH, Metalloprotease MPROT15, SARS-CoV-2-Receptor
Hersteller: AdipoGen Life Sciences
Hersteller-Nr: AG-40B-0193

Eigenschaften

Konjugat: No
Wirt: Human cells
Spezies-Reaktivität: mouse
MW: ~100 kD
Reinheit: >=95% (SDS-PAGE)
Format: Lyophilized

Handhabung & Sicherheit

Lagerung: -20°C (avoid repeat freezing and thawing cycles)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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